Overview of Pediatric Extracranial Germ Cell Tumors
نویسندگان
چکیده
منابع مشابه
Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration.
During the past 35 years, survival rates for children with extracranial malignant germ cell tumors (GCTs) have increased significantly. Success has been achieved primarily through the application of platinum-based chemotherapy regimens; however, clinical challenges in GCTs remain. Excellent outcomes are not distributed uniformly across the heterogeneous distribution of age, histologic features,...
متن کاملPediatric Germ Cell Tumors: A Developmental Perspective
Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special challenges. GCTs make up about 3% of malignancies in children aged 0-18 and nearly 15% of cancers in adolescents. Epidemiologic and molecular evidence suggests that GCTs in young children likely represent a distinct biologic group as compared to GCTs of older adolescents and adults. Despite this diffe...
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testicular germ cell tumor (tgct) is the most solid tumor in 20-40 years old man. tgct account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. tgct arise by transformation of germ cells. the transformed germ cells exhibit ploripotentially to differentiate into embryonic. extra-embryonic, and somatic tissue types, and are highly sensi...
متن کاملPediatric malignant germ cell tumors show characteristic transcriptome profiles.
Malignant germ cell tumors (GCT) of childhood are rare and heterogeneous neoplasms thought to arise from primordial germ cells. They vary substantially in their natural history and show important clinical differences from their adult counterparts. To address the biological basis for these observations, we have undertaken a comprehensive analysis of global gene expression patterns in pediatric m...
متن کاملPediatric Germ Cell Tumors; A 10-year Experience
OBJECTIVE The aim of this study was to evaluate the outcome of germ cell tumors in patients admitted to our center during a ten year period. METHODS In a retrospective descriptive study, patients with the pathological diagnosis of germ cell tumor (GCT) were included. All records were evaluated and patients followed by personal visit in clinic or phone call. Data regarding age, sex, tumor site...
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ژورنال
عنوان ژورنال: Clinical Pediatric Hematology-Oncology
سال: 2015
ISSN: 2233-5250,2233-4580
DOI: 10.15264/cpho.2015.22.1.30